Hitoshi Sakuraba Selected Research

GM2 Gangliosidoses (GM2 Gangliosidosis)

9/2016	Combined replacement effects of human modified β-hexosaminidase B and GM2 activator protein on GM2 gangliosidoses fibroblasts.
1/2016	Protease-resistant modified human β-hexosaminidase B ameliorates symptoms in GM2 gangliosidosis model.
6/2011	Therapeutic potential of intracerebroventricular replacement of modified human β-hexosaminidase B for GM2 gangliosidosis.
4/2011	Highly phosphomannosylated enzyme replacement therapy for GM2 gangliosidosis.
8/2007	Production of recombinant beta-hexosaminidase A, a potential enzyme for replacement therapy for Tay-Sachs and Sandhoff diseases, in the methylotrophic yeast Ogataea minuta.
3/2007	Therapeutic evaluation of GM2 gangliosidoses by ELISA using anti-GM2 ganglioside antibodies.
8/2006	Inefficiency in GM2 ganglioside elimination by human lysosomal beta-hexosaminidase beta-subunit gene transfer to fibroblastic cell line derived from Sandhoff disease model mice.
1/2002	Molecular and structural studies of the GM2 gangliosidosis 0 variant.

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Hitoshi Sakuraba Research Topics

Disease

43	Fabry Disease (Fabry's Disease) 01/2022 - 10/2002
14	Sandhoff Disease (Sandhoff's Disease) 01/2021 - 01/2005
13	Inborn Genetic Diseases (Disease, Hereditary) 01/2021 - 01/2004
8	Lysosomal Storage Diseases (Lysosomal Storage Disease) 09/2021 - 04/2006
8	GM2 Gangliosidoses (GM2 Gangliosidosis) 09/2016 - 01/2002
7	Tay-Sachs Disease 06/2011 - 01/2003
7	Neuraminidase deficiency with beta-galactosidase deficiency 04/2006 - 01/2002
5	Glycogen Storage Disease Type II (Pompe's Disease) 06/2011 - 01/2004
5	Mucolipidoses (Sialidosis) 03/2007 - 01/2002
4	Mucopolysaccharidosis I (Hurler Syndrome) 02/2014 - 09/2008
3	Mucopolysaccharidosis VI (Syndrome, Maroteaux-Lamy) 12/2018 - 04/2008
3	Mucopolysaccharidosis IV (Morquio Syndrome) 09/2009 - 01/2003
2	Gliosis 01/2017 - 01/2017
2	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 01/2017 - 01/2013
2	Mucopolysaccharidosis II (Hunter Syndrome) 01/2016 - 01/2016
2	Globoid Cell Leukodystrophy (Krabbe Disease) 09/2015 - 01/2014
2	Costello Syndrome 08/2008 - 08/2006
2	Nervous System Diseases (Neurological Disorders) 08/2006 - 01/2004
2	Type I Schindler Disease 01/2005 - 01/2004
2	Neuroblastoma 07/2004 - 05/2004
1	Chronic Renal Insufficiency 12/2021
1	Focal Segmental Glomerulosclerosis (Glomerulosclerosis, Focal) 12/2019
1	Nephrotic Syndrome (Syndrome, Nephrotic) 12/2019
1	Proteinuria 12/2019
1	Inflammation (Inflammations) 01/2018
1	Wilms Tumor (Wilm's Tumor) 05/2015
1	Demyelinating Diseases (Demyelinating Disease) 01/2014

Drug/Important Bio-Agent (IBA)

31	EnzymesIBA 01/2021 - 01/2002
17	GalactosidasesIBA 12/2021 - 05/2011
15	alpha-Galactosidase (Beano)IBA 01/2022 - 10/2002
13	Proteins (Proteins, Gene)FDA Link 01/2014 - 01/2002
10	globotriaosylceramide (globotriosylceramide)IBA 01/2022 - 11/2009
8	G(M2) Ganglioside (Ganglioside GM2)IBA 01/2018 - 08/2006
7	globotriaosyl lysosphingolipidIBA 09/2021 - 07/2010
6	Mannose (D-Mannose)IBA 12/2020 - 05/2004
6	Hexosaminidase A (Hex A)IBA 06/2020 - 01/2003
6	Biomarkers (Surrogate Marker)IBA 08/2018 - 07/2010
6	GlycosphingolipidsIBA 01/2018 - 02/2012
6	beta-N-AcetylhexosaminidasesIBA 08/2010 - 01/2002
5	Hexosaminidase BIBA 01/2021 - 06/2011
5	Hexosaminidases (Hexosaminidase)IBA 01/2017 - 06/2011
5	Polysaccharides (Glycans)IBA 09/2013 - 04/2005
4	GlycolipidsIBA 12/2021 - 01/2008
4	Iduronidase (alpha-L-Iduronidase)IBA 02/2014 - 09/2008
4	Messenger RNA (mRNA)IBA 01/2013 - 02/2006
4	Glycoproteins (Glycoprotein)IBA 02/2012 - 12/2002
4	Imino SugarsIBA 06/2011 - 05/2008
4	beta-Galactosidase (Lactaid)IBA 09/2009 - 01/2003
4	alpha-Glucosidases (Acid Maltase)IBA 06/2009 - 01/2004
4	5'-deoxy-5'-phosphonomethyladenosine phosphateIBA 04/2006 - 01/2002
3	agalsidase beta FDA Link 12/2020 - 01/2006
3	agalsidase alfaIBA 12/2020 - 01/2006
3	N-Acetylgalactosamine-4-Sulfatase (Arylsulfatase B)IBA 12/2018 - 04/2008
3	AntibodiesIBA 05/2015 - 03/2007
3	Amino Acids FDA Link 01/2013 - 04/2008
3	GangliosidesIBA 01/2011 - 03/2007
3	alpha-N-Acetylgalactosaminidase (N-Acetyl-alpha-D-Galactosaminidase)IBA 11/2009 - 01/2004
3	AcidsIBA 06/2009 - 01/2007
3	GlycoconjugatesIBA 03/2007 - 01/2004
3	LectinsIBA 03/2007 - 06/2004
3	Cathepsin AIBA 04/2006 - 01/2002
3	Complementary DNA (cDNA)IBA 04/2006 - 01/2002
3	Neuraminidase (Sialidase)IBA 04/2006 - 01/2002
2	Phospholipids (Phosphatides)FDA LinkGeneric 09/2021 - 10/2006
2	Pharmaceutical PreparationsIBA 09/2021 - 04/2011
2	CollagenIBA 01/2020 - 08/2008
2	Protein Isoforms (Isoforms)IBA 01/2017 - 01/2015
2	GalactosylceramidaseIBA 09/2015 - 01/2014
2	NucleotidesIBA 09/2012 - 04/2012
2	Therapeutic UsesIBA 04/2011 - 08/2006
2	TropoelastinIBA 08/2008 - 08/2006
2	SolventsIBA 08/2008 - 01/2008
2	SugarsIBA 03/2007 - 12/2002
2	Monoclonal AntibodiesIBA 03/2007 - 03/2007
1	CationsIBA 12/2020
1	Peptides (Polypeptides)IBA 01/2020
1	Cyclosporine (Ciclosporin)FDA LinkGeneric 12/2019
1	SteroidsIBA 12/2019
1	Purinergic P1 Receptors (Adenosine Receptor)IBA 10/2018
1	Fc Receptors (Fc Receptor)IBA 01/2018
1	Fingolimod Hydrochloride (FTY720)FDA Link 01/2017
1	Immunosuppressive Agents (Immunosuppressants)IBA 01/2017
1	AutoantibodiesIBA 01/2017
1	G(M2) Activator ProteinIBA 09/2016
1	Iduronic Acid (Iduronate)IBA 01/2016
1	Fluorescent Dyes (Fluorescent Probes)IBA 01/2016
1	Peptide Hydrolases (Proteases)FDA Link 01/2016
1	GlycosaminoglycansIBA 01/2016
1	podocalyxinIBA 05/2015
1	VimentinIBA 05/2015
1	migalastatIBA 07/2014
1	Psychosine (Galactosylsphingosine)IBA 01/2014
1	Heparitin Sulfate (Heparan Sulfate)IBA 09/2013
1	von Willebrand FactorIBA 04/2013
1	Platelet Membrane GlycoproteinsIBA 04/2013
1	RistocetinIBA 04/2013

Therapy/Procedure

21	Enzyme Replacement Therapy 12/2020 - 10/2002
12	Therapeutics 01/2020 - 10/2002
2	Cell Transplantation 01/2021 - 01/2020
1	Immunotherapy 12/2019